1,2,3,4,6-Penta-O-galloyl-beta-D-glucose, a bioactive compound in Elaeocarpus sylvestris extract, inhibits varicella-zoster virus replication
- Authors
- Bae, Sohee; Kim, Sun Yeou; Do, Moon Ho; Lee, Chan Hee; Song, Yoon-Jae
- Issue Date
- Aug-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Varicella zoster virus; Antiviral; 1,2,3,4,6-Penta-O-galloy1-beta-D-glucose
- Citation
- ANTIVIRAL RESEARCH, v.144, pp.266 - 272
- Journal Title
- ANTIVIRAL RESEARCH
- Volume
- 144
- Start Page
- 266
- End Page
- 272
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5845
- DOI
- 10.1016/j.antiviral.2017.06.018
- ISSN
- 0166-3542
- Abstract
- The aim of this study was to establish the effect of a 70% ethanol extract of Elaeocarpus sylvestris (ESE) on varicella-zoster virus (VZV) replication and identify the specific bioactive component(s) underlying its activity. ESE induced a significant reduction in replication of the clinical strain of VZV. Activity-guided fractionation indicated that the ethyl acetate (EtOAc) fraction of ESE contains the active compound(s) inhibiting VZV replication. High-Performance Liquid Chromatography coupled to Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry (HPLC-Q-TOF-MS/MS) analysis of the EtOAc fraction of ESE facilitated the identification of 13 chemical components. Among these, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) markedly suppressed VZV-induced c-Jun N-terminal kinase (JNK) activation, expression of viral immediate-early 62 (IE62) protein and VZV replication. Our results collectively support the utility of PGG as a potential candidate anti-viral drug to treat VZV-associated diseases. (C) 2017 Elsevier B.V. All rights reserved.
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