A Retrospective Study Investigating Risks of Acute Respiratory Distress Syndrome and Mortality Following Human Metapneumovirus Infection in Hospitalized Adults
- Authors
- Hwang, Hyunjung; Kim, Yujin; Park, Jeong-Woong; Jeong, Sung Hwan; Kyung, Sun Young
- Issue Date
- May-2017
- Publisher
- KOREAN SOC CRITICAL CARE MEDICINE
- Keywords
- metapneumovirus; mortality; nosocomial infection; respiratory distress syndrome; adult
- Citation
- ACUTE AND CRITICAL CARE, v.32, no.2, pp.182 - 189
- Journal Title
- ACUTE AND CRITICAL CARE
- Volume
- 32
- Number
- 2
- Start Page
- 182
- End Page
- 189
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6166
- DOI
- 10.4266/kjccm.2017.00038
- ISSN
- 2586-6052
- Abstract
- Background: Human metapneumovirus (hMPV) is a relatively recently identified respiratory virus that induces respiratory symptoms similar to those of respiratory syncytial virus infection in children. The characteristics of hMPV-infected adults are unclear because few cases have been reported. Methods: We conducted a retrospective review of hospitalized adult patients with a positive multiplex real-time polymerase chain reaction assay result from 2012 to 2016 at a single tertiary referral hospital in South Korea. We analyzed clinical characteristics of the enrolled patients and divided patients into an acute respiratory distress syndrome (ARDS) group and a non-ARDS group. Results: In total, 110 adults were reviewed in this study. Their mean age was 61.4 years, and the majority (n = 105, 955%) had comorbidities or were immunocompromised. Most of the patients had pneumonia on chest X-ray (n = 88, 93.6%), 22 (20.0%) had ARDS, and 12 (10.9%) expired during hospitalization. The mortality rate for patients with ARDS was higher than that of the other patients (36.4% vs. 5.7%, P = 0.001). The risk factor for hMPV-associated ARDS was heart failure (odds ratio, 5.24; P = 0.044) and laboratory values were increased blood urea nitrogen and increased C-reactive protein. The acquisition site of infection was divided into community vs. nosocomial; 43 patients (39.1%) had a nosocomial infection. The risk factors for nosocomial infection were an immunocompromised state, malignancy and immunosuppressive treatment. Conclusions: These data suggest that hMPV is one of the important respiratory pathogens important respiratory pathogen that causes pneumonia/ARDS in elderly, immunocompromised individuals and that it may be transmitted via the nosocomial route.
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