Fabrication and tissue engineering application of a 3D PPF/DEF scaffold using Blu-ray based 3D printing system
- Authors
- Kim, Jae-Hun; Lee, Jin Woo; Yun, Won-Soo
- Issue Date
- May-2017
- Publisher
- KOREAN SOC MECHANICAL ENGINEERS
- Keywords
- 3D printing; Blu-ray; Scaffold; Bioreactor; Multi-stimuli
- Citation
- JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY, v.31, no.5, pp.2581 - 2587
- Journal Title
- JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY
- Volume
- 31
- Number
- 5
- Start Page
- 2581
- End Page
- 2587
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6186
- DOI
- 10.1007/s12206-017-0456-y
- ISSN
- 1738-494X
- Abstract
- Micro-stereolithography (MSTL) among various 3D printing technologies reaches high resolution by using a focused laser beam, and therefore it can be used to fabricate objects that have feature sizes of tens to hundreds of micrometers. To fabricate a scaffold for the tissue engineering, we used a Blu-ray based MSTL system which is simpler and more compact than the conventional MSTL system. We selected a biodegradable photopolymer, Poly (propylene fumarate)/diethyl fumarate (PPF/DEF), as the construction material, and progressed post-curing to strengthen the fabricated scaffold. We seeded MC3T3-E1 pre-osteoblasts on the fabricated PPF/DEF 3D scaffolds and cultured them in a multi-stimulus bioreactor system which mimics the in-vivo shear flow environment and simultaneously supplies a magnetic field to improve cell proliferation. A cell culture result showed the superiority of combining our bioreactor system with the PPF/DEF 3D scaffold. The combination of 3D scaffold fabricated by Blu-ray based MSTL and a multi-stimulus bioreactor system may be a valuable tool for bone tissue regeneration.
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