Anti-allergic and anti-inflammatory activity of Phellinus linteus grown on Panax ginseng
- Authors
- Park, Hye-Jin
- Issue Date
- Apr-2017
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- PGP; anti-allergic activity; anti-inflammatory activity
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.26, no.2, pp.467 - 472
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 26
- Number
- 2
- Start Page
- 467
- End Page
- 472
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6272
- DOI
- 10.1007/s10068-017-0064-8
- ISSN
- 1226-7708
- Abstract
- Panax ginseng (PG) or Phellinus linteus (PL) have been widely used as traditional medicine owing to their many biological activities, including anti-inflammatory and anti-allergic activities. Previously, our group produced PL that was grown on PG media (PGP) to enhance anti-cancer activities of PGP. Here we studied the anti-allergic activity of PGP and its mechanism of action. The ethyl acetate fraction of PGP exhibited the anti-allergic activity by suppressing beta-hexosaminidase release, a marker of degranulation, from antigen/immunoglobulin E (IgE)-stimulated RBL-2H3 cells. Exposure to PGP inhibited the level of antigen/IgE-induced TNF-alpha in RBL-2H3 cells. It markedly suppressed the phosphorylation of spleen associated tyrosine kinase, GRB2-associated-binding protein 2 (Gab2) and extracellular signal-regulated kinases proteins, which are required for the degranulation and production of pro-inflammatory cytokines. Its anti-inflammatory activity was observed in lipopolysaccharide-stimulated RAW 264.7 cells. In addition, PGP contained higher contents of Rg1 than PG. Our findings suggest that PGP might be developed as a therapeutic agent for IgE-mediated allergic diseases.
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