The efficacy of fluoropyrimidine-based adjuvant chemotherapy on biliary tract cancer after R0 resection
- Authors
- Kim, Young Saing; Jeong, Chi-Young; Song, Haa-Na; Kim, Tae Hyo; Kim, Hong Jun; Lee, Young-Joon; Hong, Soon Chan
- Issue Date
- 13-Jan-2017
- Publisher
- SUN YAT SEN UNIV MED SCI WHO
- Keywords
- Biliary tract cancer; Adjuvant chemotherapy; Fluoropyrimidine; R0 resection; Prognosis
- Citation
- CHINESE JOURNAL OF CANCER, v.36
- Journal Title
- CHINESE JOURNAL OF CANCER
- Volume
- 36
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/6497
- DOI
- 10.1186/s40880-017-0182-y
- ISSN
- 1000-467X
- Abstract
- Background: The optimal treatment strategy for biliary tract cancer (BTC) after curative-intent resection remains controversial. The purpose of this study was to evaluate the efficacy of fluoropyrimidine-based adjuvant chemotherapy for BTC patients undergoing microscopically margin-negative (R0) resection. Methods: We retrospectively analyzed the clinical data of BTC patients who underwent curative-intent R0 resection. Patients were eligible if they received either fluoropyrimidine-based adjuvant chemotherapy or observation after R0 resection. Results: A total of 153 patients were included. In the entire patient cohort, no significant differences were observed in 5-year overall survival (OS) rates (48.4% vs. 39.6%, P = 0.439) or 3-year recurrence-free survival (RFS) rates (49.1% vs. 39.5%, P = 0.299) between patients who received fluoropyrimi dine-based adjuvant chemotherapy or observation. However, for patients with stages II and III BTC, chemotherapy significantly improved 5-year OS rate (52.4% vs. 35.6%, P = 0.002) and 3-year RFS rate (55.5% vs. 39.1%, P = 0.021) compared with observation. Conclusion: Fluoropyrimidine-based adjuvant chemotherapy may prolong the survival of patients with stages II and III BTC after R0 resection.
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