Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study
- Authors
- Seo, M.-S.; Hwang, I.C.; Jung, J.; Lee, H.; Choi, J.H.; Shim, J.-Y.
- Issue Date
- Jul-2020
- Publisher
- BMC
- Keywords
- Electrolyte imbalance; Hypernatremia; Prognosis; Terminal cancer
- Citation
- BMC palliative care, v.19, no.1, pp.94
- Journal Title
- BMC palliative care
- Volume
- 19
- Number
- 1
- Start Page
- 94
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/68800
- DOI
- 10.1186/s12904-020-00607-z
- ISSN
- 1472-684X
- Abstract
- BACKGROUND: Although palliative care providers, patients, and their families rely heavily on accurate prognostication, the prognostic value of electrolyte imbalance has received little attention. METHODS: As a retrospective review, we screened inpatients with terminal cancer admitted between January 2017 and May 2019 to a single hospice-palliative care unit. Clinical characteristics and laboratory results were obtained from medical records for multivariable Cox regression analysis of independent prognostic factors. RESULTS: Of the 487 patients who qualified, 15 (3%) were hypernatremic upon admission. The median survival time was 26 days. Parameters associated with shortened survival included male sex, advanced age (> 70 years), lung cancer, poor performance status, elevated inflammatory markers, azotemia, impaired liver function, and hypernatremia. In a multivariable Cox proportional hazards model, male sex (hazard ratio [HR] = 1.53, 95% confidence interval [CI]: 1.15-2.04), poor performance status (HR = 1.45, 95% CI: 1.09-1.94), leukocytosis (HR = 1.98, 95% CI: 1.47-2.66), hypoalbuminemia (HR = 2.06, 95% CI: 1.49-2.73), and hypernatremia (HR = 1.55, 95% CI: 1.18-2.03) emerged as significant predictors of poor prognosis. CONCLUSION: Hypernatremia may be a useful gauge of prognosis in patients with terminal cancer. Further large-scale prospective studies are needed to corroborate this finding.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
- 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/68800)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.