금속이온, 킬레이트 화합물과 키토산 혼합물의 항칸디다 상승 효과Synergistic Anticandidal Activity of Metal Ions, Chelating Agent and Chitosan
- Other Titles
- Synergistic Anticandidal Activity of Metal Ions, Chelating Agent and Chitosan
- Authors
- 김주원; 김선휘; 최민; 김태희; 이우진; 김정민; 이종찬; 장주영; 박제권
- Issue Date
- 2017
- Publisher
- 한국키틴키토산학회
- Keywords
- Chitosan; Candida albicans; EDTA; Divalent cations; Antibacterial effect
- Citation
- Journal of Chitin and Chitosan, v.22, no.2, pp.69 - 75
- Journal Title
- Journal of Chitin and Chitosan
- Volume
- 22
- Number
- 2
- Start Page
- 69
- End Page
- 75
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7012
- DOI
- 10.17642/jcc.22.2.1
- ISSN
- 1229-4160
- Abstract
- The potential of using chitosan as a biological agent for the control of Candida albicans was investigated. A chitosan designated as an active molecular chitosan (AMC) with average molecular weight of 8.5-kDa exhibited an effective and potential anticandidal effect at 100 mg/mL. Although metal ion Zn 2+ and EDTA had shown the significant growth inhibitory activity, but both had also shown the static effect on reversible growth inhibition, respectively, whereas AMC showed irreversible growth inhibition. In addition, anticandidal activity of those metal ions, chelating agent and a classic drug using as anticandidal agent Amphotericin B was greatly increased in the presence of AMC mg/mL. These results suggest that AMC-Zn 2+ - EDTA exerted their activities through dysregulation of the homeostasis or signaling of different cations in anticandidal effect. Thus, the combination of Zn 2+ , chelating agent EDTA and AMC may be an effective disease management strategy to prevent or delay the development of bactericidal-resistant strains.
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Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
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