Effect of acupuncture on memory function in old rats
- Authors
- 최인호; 임형호
- Issue Date
- 2017
- Publisher
- 대한한의학회
- Keywords
- Aging; acupuncture; neurogenesis; brain-derived neurotorphic factor; short-term memory; spatial memory
- Citation
- 대한한의학회지, v.38, no.2, pp.31 - 40
- Journal Title
- 대한한의학회지
- Volume
- 38
- Number
- 2
- Start Page
- 31
- End Page
- 40
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7036
- ISSN
- 1010-0695
- Abstract
- Objectives: We investigated the effect of acupuncture on memory function in relation with neurogenesis in old rats.
Methods: In this study, a step-down avoidance task for short-term memory and Y-maze task for spatial memory capability were conducted. Western blot analysis for brain-derived neurotorphic factor (BDNF) and tyrosine kinase B (TrkB), and immunohistochemistry for 5-bromo-2’-deoxyuridine (BrdU) were performed.
Results: Short-term memory and spatial memories were decreased in the old-aged rats. Expressions of BDNF and TrkB in the hippocampus were significantly decreased in the old-aged rats. Neurogenesis in the hippocampal dentate gyrus was also decreased in the old-aged rats. However, acupuncture treatment alleviated impairment of short-term and spatial memories induced by ageing. Acupuncture also increased the expressions of BDNF and TrkB and enhanced neurogenesis in the hippocampus. The present study showed that acupuncture alleviated ageing-induced short-term and spatial memory loss by increasing of BDNF and neurogenesis. Acupuncture at ST41-acupoint showed most potent effect than at ST36-acupoint or non-acupoint.
Conclusions: Acupuncture might be used as the effective therapeutic modality to ameliorate the age-related decrease of brain functions.
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