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Inductively Coupled RF Coil for Imaging a 40 µm-Thick Histology Sample in a Clinical MRI ScannerInductively Coupled RF Coil for Imaging a 40 µm-Thick Histology Sample in a Clinical MRI Scanner

Other Titles
Inductively Coupled RF Coil for Imaging a 40 µm-Thick Histology Sample in a Clinical MRI Scanner
Authors
Song Byung-PanKim Hyeong-SeopKim Kyoung-NamLee Seung-Kyun
Issue Date
Jul-2020
Publisher
한국물리학회
Keywords
MRI; RF coil; Inductive coupling; Ex-vivo; Histology
Citation
Journal of the Korean Physical Society, v.77, no.1, pp.87 - 93
Journal Title
Journal of the Korean Physical Society
Volume
77
Number
1
Start Page
87
End Page
93
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/71654
DOI
10.3938/jkps.77.87
ISSN
0374-4884
Abstract
A histology coil is a U-shaped radio-frequency (RF) coil that is designed to provide a high signal-to-noise ratio (SNR) in magnetic resonance imaging (MRI) of microscopically thin samples. In this work, we demonstrate an inductively coupled histology coil that can be easily integrated with a human MRI scanner, providing a simple method to conduct novel, microscopic imaging experiments in a clinical scanner. All experiments were conducted in a 3T whole-body MRI scanner. The coil consisted of a U-shaped copper foil with tuning capacitors shunting the ends of the “U”. This design maximizes the B1-field efficiency and the homogeneity in the coil's cavity. For inductive coupling, the histology coil was connected to an untuned single-turn pick-up loop via a coaxial cable. A standard 3T receive-only surface coil, connected to the scanner's standard receive circuitry, was then inductively coupled to the pick-up loop. Separately, the RF pulse transmitted from the MRI body coil inductively drove the histology coil. In gel phantom imaging, we confirmed a higher (threefold) SNR for the histology coil than for the scanner's standard surface coil, as well as high B1 homogeneity for the histology coil. Gradient echo images of a 40-μm-thick rat brain slice, at an in-plane resolution of 219 × 219 μm2, could be obtained with SNR > 10 (in the cortex) in about 2 hours. Our work demonstrates the feasibility of imaging microscopically thin tissue slices in a clinical MRI scanner using an inductively coupled histology coil. The method can be applied to multi-modality and multi-orientation imaging of ex-vivo and engineered tissue samples.
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