Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models
- Authors
- Lee, D.; Hong, K.-T.; Lim, T.S.; Lee, E.; Lee, Y.H.; Park, J.S.; Kim, W.; Oh, J.H.; Choi, J.-A.; Song, Y.
- Issue Date
- Jul-2020
- Publisher
- NLM (Medline)
- Keywords
- Animal model; Articular cartilage; Biomechanics; Magnetic resonance imaging; Osteoarthritis
- Citation
- BMC musculoskeletal disorders, v.21, no.1, pp.424
- Journal Title
- BMC musculoskeletal disorders
- Volume
- 21
- Number
- 1
- Start Page
- 424
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/71656
- DOI
- 10.1186/s12891-020-03447-3
- ISSN
- 1471-2474
- Abstract
- BACKGROUND: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2* relaxation time distributions. METHODS: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2* relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2* relaxation time were compared in the shoulders before and 3 months after the supraspinatus tendon resections. RESULTS: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2* relaxation time after resection surgeries. Regional changes in the articular cartilage T2* relaxation time exhibited positive correlations with regional contact strain variations 3 months after the supraspinatus resection surgeries. CONCLUSION: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2* relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas.
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