Clinicopathological characteristics of biliary neuroendocrine neoplasms: a multicenter study
- Authors
- Lee, Kyong Joo; Cho, Jae Hee; Lee, Sang Hyub; Lee, Kwang Hyuk; Park, Byung Kyu; Lee, Jun Kyu; Woo, Sang Myung; Ryu, Ji Kon; Lee, Jong Kyun; Kim, Yeon Suk; Kim, Jae Woo; Lee, Woo Jin
- Issue Date
- 2017
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- World Health Organization classification; biliary tract; neuroendocrine neoplasm; neuroendocrine carcinoma; prognosis
- Citation
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.52, no.4, pp.437 - 441
- Journal Title
- SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Volume
- 52
- Number
- 4
- Start Page
- 437
- End Page
- 441
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7516
- DOI
- 10.1080/00365521.2016.1261938
- ISSN
- 0036-5521
- Abstract
- Objectives: This study assessed the clinicopathological features, therapeutic approaches, and prognosis of patients with biliary neuroendocrine neoplasm (NENs). Materials and methods: Multicenter retrospective study of patients with biliary tract NENs in the gallbladder, the extrahepatic bile duct, or the ampulla of Vater between 2005 and 2014. Results: Total of 43 patients were included in the study. The median age was 62 years (range: 29-84 years) and 58.1% of the patients were male. The tumors occurred in the gallbladder (n = 11), the extrahepatic bile duct (n = 5) or the ampulla of Vater (n = 27). The liver was the most common metastatic site. Based on the 2010 World Health Organization classification, more patients with gallbladder NENs (11/11 (100%)) had neuroendocrine carcinoma G3 than those with NENs in the ampulla of Vater (10/27 (37.1%)). The median progression free survival time (39.3 vs 5.1 months, p = 0.001) and median overall survival time (46.9 vs 7.9 months, p<0.001) were significantly longer in patients with ampulla of Vater NENs than gallbladder NENs. A 2010 World Health Organization classification of neuroendocrine carcinoma G3 was independently related to poor overall survival (hazard ratio (HR), 27.1; 95% confidence intervals (CI), 2.81-260.68; p = 0.004). Conclusion: The 2010 World Health Organization classification of neuroendocrine carcinoma G3 was the only factor related to poor prognosis in patients with biliary neuroendocrine neoplasms.
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