Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling
- Authors
- Lee, Dahae; Ham, Jungyeob; Kang, Ki Sung; Lee, Hae-Jeung
- Issue Date
- Dec-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Cyanidin 3-O-glucoside; Glucose response; Insulin secretion; Lonicera caerulea
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.12, pp.2015 - 2018
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 37
- Number
- 12
- Start Page
- 2015
- End Page
- 2018
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7636
- DOI
- 10.1002/bkcs.11017
- ISSN
- 0253-2964
- Abstract
- Cyaniding 3-O-glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3-O-glucoside on insulin release in INS-1 cells. L. caerulea extract and cyanidin 3-O-glucoside activated the secretion of insulin that lead to diminished glucose production in INS-1 cells. Cyanidin 3-O-glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3-kinase protein expressions in INS-1 cells. These results suggest that cyanidin 3-O-glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 식품영양학과 > 1. Journal Articles
- 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7636)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.