Andrographis paniculata extract relieves pain and inflammation in monosodium iodoacetate-induced osteoarthritis and acetic acid-inducedwrithing in animal models
- Authors
- Lee, D.; Baek, C.Y.; Hwang, J.H.; Kim, M.-Y.
- Issue Date
- Jul-2020
- Publisher
- MDPI AG
- Keywords
- Analgesic; Andrographis paniculata; Anti-inflammatory; Osteoarthritis; Pain
- Citation
- Processes, v.8, no.7
- Journal Title
- Processes
- Volume
- 8
- Number
- 7
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/77452
- DOI
- 10.3390/pr8070873
- ISSN
- 2227-9717
- Abstract
- Osteoarthritis (OA), being the most prominent degenerative joint disease is affecting millions of elderly people worldwide. Although Andrographis paniculata is an ethnic medicine with a long history of being used as analgesic agent, no study using a monosodium iodoacetate (MIA) model has investigated its potential activities against OA. In this study, experimental OA was induced in rats with a knee injection of MIA, which represents the pathological characteristics of OA in humans. A. paniculata extract (APE) substantially reversed the loss of hind limb weight-bearing and the cartilage damage resulted from the OA induction in rats. Additionally, the levels of serum pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α as well as the concentration of matrix metalloproteinases, including MMP-1, MMP-3, MMP-8, and MMP-13 were decreased by APE administration. Acetic acid-induced writhing responses in mice which quantitatively measure pain were significantly reduced by APE. In vitro, APE inhibited the generation of NO and downregulated the expression of IL-1β, IL-6, COX-2, and iNOS in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The above results suggest the potential use APE as a therapeutic agent against OA. © 2020 by the authors.
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