Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain
- Authors
- Kim, Min H.; Yoon, Hargsoon; Choi, Sang H.; Zhao, Fei; Kim, Jongsung; Song, Kyo D.; Lee, Uhn
- Issue Date
- Nov-2016
- Publisher
- MDPI
- Keywords
- microspectrometer; fluorescence; dopamine; optical sensing; wireless
- Citation
- SENSORS, v.16, no.11
- Journal Title
- SENSORS
- Volume
- 16
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7754
- DOI
- 10.3390/s16111894
- ISSN
- 1424-8220
- Abstract
- Real-time monitoring of extracellular neurotransmitter concentration offers great benefits for diagnosis and treatment of neurological disorders and diseases. This paper presents the study design and results of a miniaturized and wireless optical neurotransmitter sensor (MWONS) for real-time monitoring of brain dopamine concentration. MWONS is based on fluorescent sensing principles and comprises a microspectrometer unit, a microcontroller for data acquisition, and a Bluetooth wireless network for real-time monitoring. MWONS has a custom-designed application software that controls the operation parameters for excitation light sources, data acquisition, and signal processing. MWONS successfully demonstrated a measurement capability with a limit of detection down to a 100 nanomole dopamine concentration, and high selectivity to ascorbic acid (90:1) and uric acid (36:1).
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- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
- 공과대학 > 화공생명공학과 > 1. Journal Articles
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