Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities
- Authors
- Kiem P.V.; Yen D.T.H.; Hung N.V.; Nhiem N.X.; Tai B.H.; Trang D.T.; Yen P.H.; Ngoc T.M.; Minh C.V.; Park S.; Lee J.H.; Kim S.Y.; Kim S.H.
- Issue Date
- Jun-2020
- Publisher
- MDPI
- Keywords
- Asclepiadacaea; Gymnema sylvestre; gymsyloside; pregnane; α-amylase; α-glucosidase
- Citation
- Molecules (Basel, Switzerland), v.25, no.11
- Journal Title
- Molecules (Basel, Switzerland)
- Volume
- 25
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/77555
- DOI
- 10.3390/molecules25112525
- ISSN
- 1420-3049
- Abstract
- Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A-E (1-5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-D- glucopyranosyl-(1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their α-glucosidase and α-amylase inhibitory activities. Compounds 2-4 showed significant α-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 µM.
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