High-precision low-power DNA readout interface chip for multichannel nanopore applications
- Authors
- Kim, Jungsuk; Dunbarr, William B.
- Issue Date
- 29-Oct-2016
- Publisher
- ELSEVIER SCIENCE SA
- Keywords
- Multichannel nanopore; alpha-Hemolysin; Lab-on-a-chip; DNA readout; Low noise; Single-molecule science; High throughput DNA analysis
- Citation
- SENSORS AND ACTUATORS B-CHEMICAL, v.234, pp.273 - 277
- Journal Title
- SENSORS AND ACTUATORS B-CHEMICAL
- Volume
- 234
- Start Page
- 273
- End Page
- 277
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7780
- DOI
- 10.1016/j.snb.2016.04.032
- ISSN
- 0925-4005
- Abstract
- This paper presents a high-precision and low-power DNA readout interface chip (RIC) for multichannel nanopore applications. A current-to-voltage (I/V) converter, comprising a resistive-feedback transimpedance amplifier (rf-TIA) and a difference amplifier (diff-amp), is typically used as a DNA RIC to detect minute ionic currents through a nanopore channel. However, conventional rf-TIAs require an output buffer to drive a low resistive load raised from the diff-amp, which results in high power consumption and low area efficiency on a given chip size. This diff-amp also amplifies unwanted input offset voltage, which limits output dynamics. In this work, we replace the diff-amp with a non-inverting structure to avoid the need for an output buffer, and propose a novel offset cancellation block (OCB) to drastically reduce the deleterious offset effect. This DNA RIC is fabricated in a 0.35 mu m CMOS process and is demonstrated employing an alpha-hemolysin (alpha-HL) protein nanopore and 40-mer single-stranded DNA (ssDNA) molecules. (C) 2016 Elsevier B.V. All rights reserved.
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