Phallac acids A and B, new sesquiterpenes from the fruiting bodies of Phallus luteus
- Authors
- Lee S.R.; Lee D.; Lee B.S.; Ryoo R.; Pang C.; Kang K.S.; Kim K.H.
- Issue Date
- Oct-2020
- Publisher
- Springer Nature
- Citation
- Journal of Antibiotics, v.73, no.10, pp.729 - 732
- Journal Title
- Journal of Antibiotics
- Volume
- 73
- Number
- 10
- Start Page
- 729
- End Page
- 732
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78196
- DOI
- 10.1038/s41429-020-0328-z
- ISSN
- 0021-8820
- Abstract
- Phallus luteus (Phallaceae), previously known as Dictyophora indusiata, is an edible and medicinal mushroom. As part of a continuing project to discover structurally and/or biologically novel natural products from wild mushrooms, we aimed to perform a chemical investigation of the methanol extract of P. luteus combined with a liquid chromatography–mass spectrometry-guided analysis coupled to an in-house UV spectral library. Two new sesquiterpenes, phallac acids A (1) and B (2), were isolated and determined. The chemical structure of the new natural products was unambiguously determined using a combination of 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry data. To our knowledge, this is the first study to report linear sesquiterpene carboxylic acids from P. luteus. The new compounds were evaluated for α-glucosidase inhibitory activities where phallac acid B (2) showed α-glucosidase inhibitory potential (IC50 value of 94.89 ± 5.57 μM) compared with the standard acarbose (IC50 value of 26.23 ± 1.31 μM). © 2020, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
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