Anti-inflammatory Effect of Water-soluble Chitosan Oligosaccharideson Human Monocyte THP-1 CellsAnti-inflammatory Effect of Water-soluble Chitosan Oligosaccharideson Human Monocyte THP-1 Cells
- Other Titles
- Anti-inflammatory Effect of Water-soluble Chitosan Oligosaccharideson Human Monocyte THP-1 Cells
- Authors
- Que Thanh Thanh Nguyen; Thi Xoan Hoang; 박제권; 김재영
- Issue Date
- Sep-2020
- Publisher
- 한국키틴키토산학회
- Keywords
- Chitosan; Anti-inflammation; Monocyte; Toll-like receptor 4; NF-kappaB; Cytokines
- Citation
- Journal of Chitin and Chitosan, v.25, no.3, pp.143 - 147
- Journal Title
- Journal of Chitin and Chitosan
- Volume
- 25
- Number
- 3
- Start Page
- 143
- End Page
- 147
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78391
- ISSN
- 1229-4160
- Abstract
- The various functional properties of chitosan have been investigated for use in biomedical applications. Indeed, chitosan or its derivatives have shown anti-inflammatory effect by regulating a range of cytokines, chemokines or growth factors. In the present study, we prepared water-soluble chitosan oligosaccharide (AS-WSC) by the hydrolysis of high molecular weight water-soluble chitosan (HMW-WSC) and examined its anti-inflammatory effect on LPS-stimulated human monocytic THP-1 cells. Our results revealed that LPS-induced NF-κB activity of THP-1 cells was significantly suppressed by treatment with 0.02% AS-WSC. In addition, 0.02% AS-WSC treatment down-regulated the expression of Toll-like receptor 4 and inflammatory cytokines, such as IL-1β and TNF-α, but had no effect on IL-10 and IL-4 expression in LPS-stimulated THP-1 cells. Our results suggest that 0.02% AS-WSC can be considered as a promising anti-inflammatory agent.
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