Traditional Korean diet can alter the urine organic acid profile, which may reflect the metabolic influence of the diet한식의 체내 대사에 미치는 영향에 대한 연구 : 소변 유기산 분석을 통한 한식의 효과
- Other Titles
- 한식의 체내 대사에 미치는 영향에 대한 연구 : 소변 유기산 분석을 통한 한식의 효과
- Authors
- 신필경; 천수경; 김명선; 박선주; 김민정; 권대영; 김경철; 이해정; 최상운
- Issue Date
- Jun-2020
- Publisher
- 한국영양학회
- Keywords
- Korean diet; urine organic acid; succinate; hydroxymethylglutarate; kynurenate
- Citation
- Journal of Nutrition and Health, v.53, no.3, pp.231 - 243
- Journal Title
- Journal of Nutrition and Health
- Volume
- 53
- Number
- 3
- Start Page
- 231
- End Page
- 243
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78428
- DOI
- 10.4163/jnh.2020.53.3.231
- ISSN
- 2288-3886
- Abstract
- Purpose: To determine the metabolic influence of the traditional Korean diet (K-diet), which has been regarded as a healthy diet, we investigated the profile of urine organic acids that are intermediates of various types of metabolism including energy metabolism.
Methods: Ten women aged 50–60 years were recruited and randomly divided into 2 diet groups, K-diet and control diet, the latter of which is a Westernized Korean diet that is commonly consumed by Koreans nowadays. Before and after the 2-week intervention, 46 urine organic acids were determined using LC/MS/MS, along with clinical parameters.
Results: The average concentrations of succinate (4.14 ± 0.84 µg/mg creatinine vs. 1.49 ± 0.11, p = 0.0346) and hydroxymethylglutarate (3.67 ± 0.36 µg/mg creatinine vs. 2.97 ± 0.29, p = 0.0466), both of which are intermediates of energy metabolism, decreased in the K-diet group after the 2-week intervention, but these were not observed in the control diet group.
In particular, the average concentration of succinate in the K-diet group was lower than that in the control group (3.33 ± 0.56 µg/mg creatinine vs. 1.49 ± 0.11, p = 0.0284) after 2 weeks.
The concentrations of two tryptophan metabolites, 5-hydroxyindolacetate (3.72 ± 0.22 µg/mg creatinine vs. 3.14 ± 0.21, p = 0.0183) and indican (76.99 ± 8.35 µg/mg creatinine vs. 37.89 ± 10.06, p = 0.0205) also decreased only in the K-diet group. After the 2-week intervention, the concentration of kynurenate, another tryptophan metabolite, was lower in the K-diet group than that in the control diet group (3.96 ± 0.51 µg/mg creatinine vs. 2.90 ± 0.22, p = 0.0356).
Interestingly, the urine level of kynurenate was positively correlated with BMI (r = 0.61424, p = 0.0003) and total cholesterol (r = 0.46979, p = 0.0088), which decreased only in the K-diet group (239.40 ± 15.14 mg/dL vs. 198.20 ± 13.25, p = 0.0163).
Conclusion: The K-diet alters the urinary excretion of organic acids involved in energy metabolism and tryptophan metabolism, suggesting the influence of the K-diet on these types of metabolism. Urine organic acids changed by the K-diet may serve as biomarkers in future studies.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 식품영양학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/78428)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.