Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus
- Authors
- Ryu, Se Hwan; Hong, Seong Min; Khan, Zahra; Lee, Seul Ki; Vishwanath, Manjunatha; Turk, Ayman; Yeon, Sang Won; Jo, Yang Hee; Lee, Dae Hee; Lee, Jae Kang; Hwang, Bang Yeon; Jung, Jae-Kyung; Kim, Sun Yeou; Lee, Mi Kyeong
- Issue Date
- Jan-2021
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Hericium erinaceus; Hericiaceae; Isoindolinone; Neurotrophic factor; Neurite outgrowth; Isohericerinol A
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.31
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 31
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79697
- DOI
- 10.1016/j.bmcl.2020.127714
- ISSN
- 0960-894X
- Abstract
- Four compounds, hericerin (1), isohericerinol A (2), N-de-phenylethyl isohericerin (3) and corallocin A (4) were isolated from the fruiting bodies of Hericium erinaceus, a lion's mane mushroom (Hericiaceae). Among them, isohericerinol A (2) was newly reported in nature. Further investigation of the neurotrophic effect of isolated compounds demonstrated that isohericerinol A (2) strongly increased the nerve growth factor (NGF) production in C6 glioma cells followed by corallocin A (4) and hericerin (1). Increased NGF production by these compounds promoted the neurite outgrowth in N2a neuronal cells. Western blot analysis also showed the increased protein expression of NGF, brain-derived neurotrophic factor (BDNF) and synaptophysin (SYP) in C6-N2a cells. Taken together, our present study characterized the neurotrophic constituents of H. erinaceus, which may support the potential use of memory improvement.
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