Cough persistence in adults with chronic cough: A 4-year retrospective cohort study
- Authors
- Kang, Sung-Yoon; Song, Woo-Jung; Won, Ha-Kyeong; Chung, Soo Jie; Kim, Ju-Young; Park, Heung-Woo; Morice, Alyn H.; Cho, Sang-Heon
- Issue Date
- Oct-2020
- Publisher
- Japanese Society of Allergology
- Keywords
- Chronic cough; Epidemiology; Longitudinal outcome; Predictor; Retrospective cohort study
- Citation
- Allergology International, v.69, no.4, pp.588 - 593
- Journal Title
- Allergology International
- Volume
- 69
- Number
- 4
- Start Page
- 588
- End Page
- 593
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79882
- DOI
- 10.1016/j.alit.2020.03.012
- ISSN
- 1323-8930
- Abstract
- Background: There is very limited evidence regarding long-term prognosis of chronic cough. We examined longitudinal outcomes among patients with chronic cough, and explored predictors of cough persistence. Methods: A retrospective cohort was constructed of adults who had newly visited a specialist cough clinic in 2012–2013. All had undergone systematic investigation for chronic cough. The Hull Airway Reflux Questionnaire (HARQ) was administered to assess reflux cough symptoms. A follow-up survey was conducted in 2016–2017 to assess cough persistence. Results: From 418 candidates, 323 participated in the follow-up study; main analyses focused on patients with chronic persistent cough (n = 64; 19.8%) and remitted cough (n = 193; 59.8%). Compared with remitted cough group, chronic persistent cough group had more family history of chronic cough (17.2% vs. 4.7%, p = 0.001) and cold air-sensitive cough (62.5% vs. 44.6%, p = 0.013). The total HARQ score did not differ; however, two items (cough with eating and cough with certain foods) scored significantly higher in chronic persistent cough. In multivariate analyses, a family history of chronic cough (adjusted odds ratio 4.27 [95% confidence interval 1.35–9.89]), cold air-sensitive cough (2.01 [1.09–3.73]), and cough with eating (1.22 [1.02–1.45]) were associated with chronic persistent cough at 4 years. Conclusions: Cough persists in about 20% of patients after 4 years following systematic assessment and treatments. Several cough characteristics, such as family history, cold air-sensitivity, or reflux cough, may be associated with cough persistence. Larger cohort studies are warranted to further understand long-term prognosis and confirm predictors of persistence in patients with chronic cough. © 2020 Japanese Society of Allergology
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