Experimental study on gastroprotective efficacy and mechanisms of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn. in different experimental models
- Authors
- Antonisamy, Paulrayer; Subash-Babu, Pandurangan; Albert-Baskar, Arul; Alshatwi, Ali A.; Aravinthan, Adithan; Ignacimuthu, Savarimuthu; Choi, Ki Choon; Lee, Sung Cheol; Kim, Jong-Hoon
- Issue Date
- Aug-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Gastroprotective activity; Ethanol-induced gastric injury; Oxidative stress; Apoptosis; LUT7G; Ophiorrhiza mungos
- Citation
- JOURNAL OF FUNCTIONAL FOODS, v.25, pp.302 - 313
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- Volume
- 25
- Start Page
- 302
- End Page
- 313
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8040
- DOI
- 10.1016/j.jff.2016.06.003
- ISSN
- 1756-4646
- Abstract
- The gastroprotective effect of luteolin-7-O-glucoside (LUT7G) on different ulcer models using rats including the indomethacin model, the ethanol-induced gastric ulcer model and the Shay ulcer model was examined. The ethanol-induced ulcer group showed significant increases in MPO, NO, iNOS, MMP-2, MMP-9, caspase-3, apoptosis, IL-6, TNF-alpha, IKK, NF-kappa B, p65, and ICAM-1 and declines in PGE2, arginase, SOD, GSH, mucin, IL-10, eNOS, COX-1, HSP-70, and I kappa B alpha levels. However, LUT7G (25 mg/kg) pretreatment significantly reverted the pathophysiological levels of these biomarkers to near normal levels. The gastroprotective activity of LUT7G was abolished by pretreatment with SC560, rofecoxib, and L-NAME, demonstrating the participation of COX and NOS in LUT7G-facilitated gastroprotection against ethanol induced ulcers. Convincingly, LUT7G (25 mg/kg) provided protective effects in the rat gastric mucosa against ethanol-induced gastric injury at least in part to antisecretory, anti-inflammatory, antioxidative, and antiapoptotic activity, and augmentation of PGE2, mucin and HSP-70 synthesis. (C) 2016 Elsevier Ltd. All rights reserved.
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