Cancer Cell Detection on the Surface of Top-Gated Monolayer Graphene via Raman Spectroscopy
- Authors
- Nanda, S.S.; Kaushal, S.; Shin, Yong; Yun, Kyusik; An, Seong Soo A.; Hembram, K.P.S.S.; Papaefthymiou, G.C.; Yi, Dong Kee
- Issue Date
- Feb-2021
- Publisher
- American Chemical Society
- Keywords
- biosensor; cancer cell; DFT; graphene; Raman spectroscopy
- Citation
- ACS Applied Bio Materials, v.4, no.2, pp.1493 - 1498
- Journal Title
- ACS Applied Bio Materials
- Volume
- 4
- Number
- 2
- Start Page
- 1493
- End Page
- 1498
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80535
- DOI
- 10.1021/acsabm.0c01377
- ISSN
- 2576-6422
- Abstract
- A label-free biosensor is described based on the Raman spectroscopic signatures of monolayer graphene, which are modified in the compartment of cancer cells because of electron-phonon coupling in monolayer graphene. Specifically, the Raman spectra of electrostatically gated monolayer graphene on SiO2/Si substrates, in the voltage range from 0 to 5 V, were studied in the absence and the presence of cancer cells. Density functional theory simulations afforded a correlation between cancer cells and the observed Raman spectra, through the regulation of the intensities of the G and 2D Raman vibrational modes with applied voltage. The C-H and N-H bonds of phenylalanine enabled the detection of this biosensing activity. Significantly, this detection can be carried out even in the absence of cancer cell-culturing steps. ©
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