Evaluation of the effects of Hangover-releasing agent containing freeze-dried mature silkworm larval powder (SMSP) on alcohol metabolism and hangover improvement숙잠 함유 복합물의 알코올 대사 및 숙취개선 효능평가
- Other Titles
- 숙잠 함유 복합물의 알코올 대사 및 숙취개선 효능평가
- Authors
- 우미선; 차지현; 김희택; 김현덕; 조경원; 박성선; 이종훈
- Issue Date
- Feb-2021
- Publisher
- 한국식품과학회
- Keywords
- hangover improvement; silkworm (Bombyx mori) powder; alcohol metabolism; clinical trail research; cross-over model
- Citation
- 한국식품과학회지, v.53, no.1, pp.72 - 77
- Journal Title
- 한국식품과학회지
- Volume
- 53
- Number
- 1
- Start Page
- 72
- End Page
- 77
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80581
- DOI
- 10.9721/KJFST.2021.53.1.72
- ISSN
- 0367-6293
- Abstract
- Silkworms have traditionally been used to produce silk and textiles. However, steamed and freeze-dried mature silkworm larval powder (SMSP) contain large amounts of amino acids, vitamins, and essential minerals. In this study, we investigated the potential of SMSP as a hangover-relieving agent. Thirty individuals who met the selection criteria and exclusion criteria were included in the study and subsequently underwent a double-blind, randomized, placebo-controlled, cross-design human application test. Importantly, the test product containing SMSP (CKDHC) was proven to alleviate hangovers through a significant reduction in the plasma concentration of acetaldehyde in the context of an alcohol-induced hangover model. In particular, from 0.5 h after SMSP intake, the blood acetaldehyde concentration (mg/L), area under the time curve (AUC; indicating the degree of bioabsorption of blood acetaldehyde), and the highest blood acetaldehyde concentration (Cmax) were reduced. Altogether, these results suggest that the test product (CKDHC) exhibits an accelerated hangover-relieving effect.
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