Surface Functionalization of Doxorubicin loaded MCM-41 Mesoporous Silica Nanoparticles by 3-Aminopropyltriethoxysilane for Selective Anticancer 9 Effect on A549 and A549/DOX Cells
- Authors
- Dau, T.A.N.; Le, V.M.H.; Pham, T.K.H.; Le, V.H.; Cho, S.K.; Nguyen, T.N.U.; Ta, T.K.H.; Van, Tran T.T.
- Issue Date
- May-2021
- Publisher
- SPRINGER
- Keywords
- A549; A549/DOX; doxorubicin; MCM-41; Mesoporous silica nanoparticles
- Citation
- Journal of Electronic Materials, v.50, no.5, pp.2932 - 2939
- Journal Title
- Journal of Electronic Materials
- Volume
- 50
- Number
- 5
- Start Page
- 2932
- End Page
- 2939
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80839
- DOI
- 10.1007/s11664-021-08813-y
- ISSN
- 0361-5235
- Abstract
- Abstract: In this study, MCM-41 mesoporous silica nanoparticles were successfully synthesized by the condensation of a tetraorthosilicate precursor on a template self-assembled by cetyltrimethylammonium bromide in alkaline. The small-angle x-ray diffraction patterns of MCM-41 indicate that silica nanoparticles possess hexagonal structures with a high degree of structural ordering. Transmission electron microscopy images show that the size of the MCM-41 particles is around 100-120 nm, and the pore sizes range from 2 nm to 4 nm. In addition, the specific surface area of MCM-41 obtained by Brunauer–Emmett–Teller analysis is as high as 987 m2.g−1 and the pore size extracted from nitrogen physical adsorption isotherms is in accordance with the TEM result. Thermogravimetric analysis, Fourier-transform infrared spectroscopy, Zeta potential measurements and photoluminescence measurements show that 3-aminopropyltriethoxysilane (APTES) and doxorubicin were grafted and loaded successfully onto MCM-41 nanoparticles. An assay on fibroblasts, A549 and doxorubicin-resistant A549/DOX cells indicates that the prepared MCM41 grafting APTES nanoparticles are safe to normal cells and toxic to cancer cells in vitro. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Minerals, Metals & Materials Society.
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