Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits
- Authors
- Yu, Jimin; Cho, Eunbi; Kwon, Huiyoung; Jeon, Jieun; Sin, Jae Seong; Park, Jun Kwon; Kim, Ji-Su; Choi, Ji Woong; Park, Se Jin; Jun, Mira; Lee, Young Choon; Ryu, Jong Hoon; Lee, Jeongwon; Moon, Minho; Lee, Seungheon; Cho, Jong Hyun; Kim, Dong Hyun
- Issue Date
- Feb-2021
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Akt; Alzheimer' s disease; Calcium-permeable AMPA receptor; Long-term potentiation; Pinoresinol
- Citation
- Biochemical Pharmacology, v.184
- Journal Title
- Biochemical Pharmacology
- Volume
- 184
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80985
- DOI
- 10.1016/j.bcp.2020.114366
- ISSN
- 0006-2952
- Abstract
- Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by memory deficits. Although no drug has given promising results, synaptic dysfunction-modulating agents might be considered potential candidates for alleviating this disorder. Pinoresinol, a lignan found in Forsythia suspensa, is a memory-enhancing agent with excitatory synaptic activation. In the present study, we tested whether pinoresinol reduces learning and memory and excitatory synaptic deficits in an amyloid β (Aβ)-induced AD-like mouse model. Pinoresinol enhanced hippocampal long-term potentiation (LTP) through calcium-permeable AMPA receptor, which was mediated by Akt activation. Moreover, pinoresinol ameliorated LTP deficits in amyloid β (Aβ)-treated hippocampal slices via Akt signaling. Oral administration of pinoresinol ameliorated Aβ-induced memory deficits without sensory dysfunction. Moreover, AD-like pathology, including neuroinflammation and synaptic deficit, were ameliorated by pinoresinol administration. Collectively, pinoresinol may be a good candidate for AD therapy by modulating synaptic functions. © 2020
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