A Brief Review of the Mechanisms of beta-Cell Dedifferentiation in Type 2 Diabetes
- Authors
- Khin, Phyu-Phyu; Lee, Jong-Han; Jun, Hee-Sook
- Issue Date
- May-2021
- Publisher
- MDPI
- Keywords
- ER stress; Long non-coding RNAs; MicroRNAs; Oxidative stress; Type 2 diabetes; β-cell dedifferentiation
- Citation
- NUTRIENTS, v.13, no.5
- Journal Title
- NUTRIENTS
- Volume
- 13
- Number
- 5
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81396
- DOI
- 10.3390/nu13051593
- ISSN
- 2072-6643
- Abstract
- Diabetes is a metabolic disease characterized by hyperglycemia. Over 90% of patients with diabetes have type 2 diabetes. Pancreatic β-cells are endocrine cells that produce and secrete insulin, an essential endocrine hormone that regulates blood glucose levels. Deficits in β-cell function and mass play key roles in the onset and progression of type 2 diabetes. Apoptosis has been considered as the main contributor of β-cell dysfunction and decrease in β-cell mass for a long time. However, recent studies suggest that β-cell failure occurs mainly due to increased β-cell dedifferentiation rather than limited β-cell proliferation or increased β-cell death. In this review, we summarize the current advances in the understanding of the pancreatic β-cell dedifferentiation process including potential mechanisms. A better understanding of β-cell dedifferentiation process will help to identify novel therapeutic targets to prevent and/or reverse β-cell loss in type 2 diabetes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.