Identification of gallic acid as a active ingredient of Syzygium aromaticum against tacrolimus-induced damage in renal epithelial LLC-PK1 cells and rat kidney
- Authors
- Lee, Ji Hwan; Park, Musun; Jung, Kiwon; Hong, Gyeongmin; Lee, Hye Lim; Kim, Dong-Wook; Kim, Chang-Eop; Kang, Ki Sung
- Issue Date
- 1-Jun-2021
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- FK506; Gallic acid; Nephrotoxicity; Tacrolimus
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.41
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 41
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81528
- DOI
- 10.1016/j.bmcl.2021.128012
- ISSN
- 0960-894X
- Abstract
- Tacrolimus (FK506), a calcineurin inhibitor, is an effective immunosuppressive agent mainly used to lower the risk of organ rejection after allogeneic organ transplant. However, FK506-associated adverse effects, such as nephrotoxicity, may limit its therapeutic use. In this study, we confirmed that epigallocatechin-3-gallate (EGCG), sanguiin H-6, and gallic acid increased cell survival following FK506-induced cytotoxicity in renal epithelial LLC-PK1. Among these compounds, gallic acid exerted the strongest protective effect, further confirmed in the FK506-induced nephrotoxicity rat model. Additionally, we identified supporting evidence for the nephroprotective function of gallic acid using molecular docking and bioavailability investigations. © 2021 Elsevier Ltd
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