Liquid Crystal-Based Droplet Sensor for the Detection of Hg(II) Ions Using an Aptamer as the Recognition Element
- Authors
- Hong, P.T.K.; Yun, Kyusik; Jang, Chang-Hyun
- Issue Date
- Jun-2021
- Publisher
- KOREAN BIOCHIP SOCIETY-KBCS
- Keywords
- 4-cyano-4′-pentylbiphenyl; Detection of Hg2+; Liquid crystal-based droplet sensor; Liquid crystals; Mercury ions
- Citation
- BIOCHIP JOURNAL, v.15, no.2, pp.152 - 161
- Journal Title
- BIOCHIP JOURNAL
- Volume
- 15
- Number
- 2
- Start Page
- 152
- End Page
- 161
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81535
- DOI
- 10.1007/s13206-021-00010-7
- ISSN
- 1976-0280
- Abstract
- Herein, we report the development of a simple liquid crystal (LC)-based droplet sensor for the specific detection of mercury ions (Hg2+) in an aqueous medium, using trimethyl octadecyl ammonium bromide (OTAB) and an Hg2+-binding aptamer. In terms of the mechanism, the system senses the homeotropic orientation of the LCs at the LC–aqueous interface that is induced by the self-assembled monolayer of positively charged OTAB molecules. In the absence of Hg2+, electrostatic interactions between the positively charged OTAB and negatively charged aptamer molecules disturb the organization of the OTAB monolayer, causing the LCs to adopt a planar orientation. By contrast, an aptamer hairpin structure formed in the presence of Hg2+ weakens the interactions between the OTAB and aptamer molecules, causing the OTAB monolayer to self-reassemble and the LCs to consequently adopt a homeotropic orientation. These LC orientational transitions are observable under a polarized optical microscope. This sensor had a low limit of detection of 100 and 250 pM for buffer and tap water samples, respectively. Therefore, our LC-based droplet sensor is a suitable platform for the simple, specific, and convenient detection of Hg2+ in an aqueous medium. © 2021, The Korean BioChip Society.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 나노화학과 > 1. Journal Articles
- 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81535)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.