sFlt-1/PlGF ratio as a predictive and prognostic marker for preeclampsia
- Authors
- Jeon, Hae Rin; Jeong, Da Hoe; Lee, Jin Young; Woo, Eun Young; Shin, Gwi Taek; Kim, Suk-Young
- Issue Date
- Jul-2021
- Publisher
- WILEY
- Keywords
- hypertension; PlGF; preeclampsia; sFlt-1/PlGF ratio; sFtl-1
- Citation
- JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, v.47, no.7, pp.2318 - 2323
- Journal Title
- JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
- Volume
- 47
- Number
- 7
- Start Page
- 2318
- End Page
- 2323
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81649
- DOI
- 10.1111/jog.14815
- ISSN
- 1341-8076
- Abstract
- Objective: Preeclampsia is clinically unpredictable and associated with adverse outcomes. Pregnant women with suspected preeclampsia require intensive monitoring or hospitalization for elevated sFlt-1 (soluble fms-like tyrosine kinase-1) to PlGF (placental growth factor) ratios before symptoms arise. We aimed to determine the sFlt-1/PlGF ratio's usefulness in predicting adverse pregnancy outcomes in preeclampsia. Methods: From January 2017 to February 2019, we measured the sFlt-1/PlGF ratio in 73 singleton pregnant women suspected of preeclampsia and classified them into three groups: low-risk (sFlt-1/PlGF ratio < 38, n = 19), intermediate (38 <= ratio < 85, n = 9), and high-risk (ratio >= 85, n = 32). Results: Although the low- and high-risk groups both experienced weight gain during pregnancy, their body mass index (BMI) differed after pregnancy (p = 0.004). The number of women who had been taking antihypertensive medications for chronic hypertension since early pregnancy was higher in the low-risk group (31.6% vs. 22.2%, 6.7%). The gestational weeks at birth were lower in the high-risk group compared to that of the low-risk group (32.0 weeks vs. 35.79 weeks, p < 0.001). In the high-risk group, the average neonatal weight was significantly lighter (p = 0.021), and the period of stay in the neonatal intensive care unit was longer than that in the low-risk group (p = 0.003). Conclusion: The sFlt-1/PlGF ratio is a useful indicator of preeclampsia severity and can be utilized as a prognostic marker.
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