Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model
- Authors
- Adhikari, Nirpesh; Prasad Aryal, Yam; Jung, Jae-Kwang; Ha, Jung-Hong; Choi, So-Young; Kim, Ji-Youn; Lee, Tae-Hoon; Kim, Sang-Hyun; Yamamoto, Hitoshi; Suh, Jo-Young; An, Chang-Hyeon; Lee, Youngkyun; Sohn, Wern-Joo; An, Seo-Young; Kim, Jae-Young
- Issue Date
- Aug-2021
- Publisher
- WILEY
- Keywords
- bone regeneration; cytokine; inflammation; periodontitis model; tooth loss
- Citation
- Journal of Periodontal Research, v.56, no.4, pp.735 - 745
- Journal Title
- Journal of Periodontal Research
- Volume
- 56
- Number
- 4
- Start Page
- 735
- End Page
- 745
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81700
- DOI
- 10.1111/jre.12870
- ISSN
- 0022-3484
- Abstract
- Objective: To evaluate the effect of resveratrol on periodontal bone regeneration after local delivery and to determine its effect on inflammatory mediators. Background: Resveratrol is considered an anti-inflammatory polyphenolic stilbene involved in the modulation of inflammation. Materials and Methods: Periodontitis was induced in mouse molars using a 5-day ligature model followed by the left second molar extraction and 50 µM resveratrol treatment for 1 and 2 weeks. We then examined specimens treated for 1 week histologically and with immunostaining. Microfocus-computed tomography (micro-CT) was used to examine the bone volume formation. Results: After 1 week of treatment, proinflammatory cytokine levels (TNF-alpha and IL6), cells exhibiting neutrophil and macrophage marker (MPO), cell proliferation marker (Ki67), and preosteoblastic marker (RUNX2) reactivity decreased in the resveratrol-treated specimens compared to the control group. In contrast, we observed a higher number of CD31-, F4/80-, and osteocalcin- (OCN-) positive cells in the resveratrol-treated specimens. After 2 weeks, micro-CT confirmed an increased bone mass in the region of the extraction socket in the resveratrol-treated group. Conclusion: After 1 week, the resveratrol-treated specimens revealed evidence of inflammation modulation compared to the control group. These data suggest that resveratrol not only affects inflammation control but also is useful for treating periodontitis-related tissue defects and bone regeneration. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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