Nanosilver-embedded silicon nanowires as a SERS-active substrate for the ultrasensitive detection of monoamine neurotransmitters
- Authors
- Vo, Van-The; Phung, Viet-Duc; Lee, Sang-Wha
- Issue Date
- Aug-2021
- Publisher
- ELSEVIER
- Keywords
- Dopamine; Nanosilver-embedded; Serotonin; SERS; Silicon nanowires
- Citation
- Surfaces and Interfaces, v.25
- Journal Title
- Surfaces and Interfaces
- Volume
- 25
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81850
- DOI
- 10.1016/j.surfin.2021.101181
- ISSN
- 2468-0230
- Abstract
- The trace detection of neurotransmitters is very useful in the diagnosis of severe neuropsychiatric diseases such as Parkinson's, Schizophrenia, and Depression. Surface enhanced Raman scattering (SERS) is a prospective technique for the sensitive detection of analyte with molecular information. Herein, a porous silicon (pSi) template (so-called silicon nanowires) was prepared using a metal-assisted chemical etching process, and the pSi template was successfully embedded with plenty of nanosilvers. The nanosilver-embedded pSi (pSi@Ag) was employed as a SERS-active substrate to detect dopamine (DA) and serotonin (ST) neurotransmitters at ultralow concentrations. The optimized pSi@Ag substrate produced an excellent dynamic linear range over six orders of magnitude (from 10−6 to 10−12 M), as well as showing the picomolar detection limit of ~10−13 M. The substrate exhibited the comparable performance to the current state-of-the-art researches, probably because the SERS signals were generated from larger number of analyte molecules adsorbed on the internal silver nanostructures with porous layer. Furthermore, the pSi@Ag substrate distinguished the individual component in the mixture (DA and ST at 10−8 M) without any labelling, corroborating the reliable pSi@Ag substrate for the application to the actual biological fluid. © 2021
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