Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection
- Authors
- Kim, Sung Gun; Lee, Jun Seop
- Issue Date
- 14-Aug-2021
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- JOURNAL OF MATERIALS CHEMISTRY B, v.9, no.30, pp.6076 - 6083
- Journal Title
- JOURNAL OF MATERIALS CHEMISTRY B
- Volume
- 9
- Number
- 30
- Start Page
- 6076
- End Page
- 6083
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81856
- DOI
- 10.1039/d1tb00582k
- ISSN
- 2050-7518
- Abstract
- Nesfatin-1 (NES1) is a potential biomarker found in serum and saliva that indicates hyperpolarization and depolarization in the hypothalamic ventricle nucleus as well as an increase in epileptic conditions. However, real-time investigations have not been carried out to detect changes in the concentration of NES1. In this study, we develop a multiscale pore contained carbon nanofiber-based field-effect transistor (FET) biosensor to detect NES1. The activated multiscale pore contained carbon nanofiber (a-MPCNF) is generated using a single-nozzle co-electrospinning method and a subsequent steam-activation process to obtain a signal transducer and template for immobilization of bioreceptors. The prepared biosensor exhibits a high sensitivity to NES1. It can detect levels as low as 0.1 fM of NES1, even in the presence of other interfering biomolecules. Furthermore, the a-MPCNF-based FET sensor has significant potential for practical applications in non-invasive real-time diagnosis, as indicated by its sensing performance in artificial saliva.
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Collections - 공과대학 > 신소재공학과 > 1. Journal Articles
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