A Flounder Fish Peptide Shows Anti-Hypertensive Effects by Suppressing the Renin-Angiotensin-Aldosterone System and Endothelin-1
- Authors
- Rahmdel, Mohamad; Cho, Sang Min; Jeon, You-Jin; Lee, Dae Ho
- Issue Date
- Aug-2021
- Publisher
- BENTHAM SCIENCE PUBL LTD
- Keywords
- Spontaneously hypertensive rat; antihypertensive agent; endothelin-1; renin-angiotensin system; aldosterone; an-giotensin II; SHR
- Citation
- PROTEIN AND PEPTIDE LETTERS, v.28, no.7, pp.831 - 840
- Journal Title
- PROTEIN AND PEPTIDE LETTERS
- Volume
- 28
- Number
- 7
- Start Page
- 831
- End Page
- 840
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81906
- DOI
- 10.2174/0929866528666210211142105
- ISSN
- 0929-8665
- Abstract
- Background: Many fishes have been known for their good nutritional effects especially in the cardiovascular aspect. Some specific fish peptides have anti-hypertensive effects. Objective: In the present study, we hypothesized that the hexapeptide (MEVFVP) from flounder fish muscle can be a potent antihypertensive peptide, therefore, decided to perform this experiment. Methods: The peptide MEVFVP from flounder fish muscle (40 mg/kg) and vehicle were administered per os to spontaneously hypertensive rats (SHRs) (SHR-M and SHR-C, respectively). Additionally, plasma MEVFVP was measured serially before and after its oral administration to Sprague Dawley rats. Results: Blood pressures (BPs), especially systolic BP, in SHR rats were decreased around 3-6 hours after MEVFVP administration. Compared with SHR-C rats, endothelin-1 (ET-1) mRNA expression in multiple tissues, and plasma levels of ET-1, angiotensin II, and aldosterone were lower in SHR-M rats, whereas the phosphorylation of AMP-activated protein kinase (AMPK) was increased in the kidney of SHR-M rats. The administered peptide was not detected in rat plasma, while ex vivo incubation of the peptide in rat plasma caused its rapid degradation within minutes. Conclusion: Our results show that the MEVFVP has an antihypertensive effect by regulating renin-angiotensin-aldosterone system, ET-1 and AMPK despite its limited bioavailability.
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