Neuroprotective effects on amyloid-beta induced cytotoxicity of Pandanus clementis Merr
- Authors
- Tan, M.A.; Tan, B.L.U.; Nonato, M.G.; An, S.S.A.
- Issue Date
- Jul-2021
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Alzheimer’s disease; Amyloid-beta; Neuroprotection; Pandanus
- Citation
- 3 Biotech, v.11, no.7
- Journal Title
- 3 Biotech
- Volume
- 11
- Number
- 7
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82094
- DOI
- 10.1007/s13205-021-02889-3
- ISSN
- 2190-572X
- Abstract
- The present study determined the neuroprotective potential of the alcoholic and aqueous extracts of Pandanus clementis Merr. (Pandanaceae) to protect the neuroblastoma SH-SY5Y cells against amyloid-beta1-42 (Aβ) cytotoxicity. Inhibition of Aβ aggregation was determined by Thioflavin T (ThT) assay, and in vitro neuroprotective cell viability, intracellular reactive oxygen species (ROS), and mitochondrial membrane potential (MMP) were evaluated with human neuroblastoma SH-SY5Y cells insulted with Aβ. Chromatographic separation on the alcoholic extract yielded known phytosterols. Results showed that pretreatment of the SH-SY5Y cells with the P. clementis extracts increased cell viability and MMP, and decreased ROS, suggesting protective effects. Hence, P. clementis extract has promising neuroprotective therapeutic potential. © 2021, King Abdulaziz City for Science and Technology.
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