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Enhanced proliferation of rabbit chondrocytes by using a well circulated nanoshock system

Authors
Nanda, Sitansu SekharWang, TuntunYoon, Hong YeolAn, Seong Soo A.Hembram, K.P.S.S.Kim, KwangmeyungYi, Dong Kee
Issue Date
Sep-2021
Publisher
Nature Research
Citation
Scientific Reports, v.11, no.1
Journal Title
Scientific Reports
Volume
11
Number
1
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82403
DOI
10.1038/s41598-021-98929-2
ISSN
2045-2322
Abstract
The gold nanorods (GNRs) embedded alginate-chitosan (scaffold), which was designed and fabricated to produce efficient handling of the cell proliferations. Scaffold embedded GNR (SGNR) and NIR (near infrared) irradiations are developing into an interesting medical prognosis tool for rabbit chondrocyte (RC) proliferation. SGNR contained a pattern of uniform pores. Biocompatibility and cellular proliferation achieved by disclosures to NIR irradiations, providing high cell survival. SGNR and NIR irradiations could produce mechanical and biochemical cues for regulating RCs proliferations. To determine the thermal stress, it exposed RCs to 39–42 °C for 0–240 min at the start point of the cell culture cycle. It produced photothermal stress in cellular surrounding (cells located adjacent to and within scaffold) and it deals with the proliferation behavior of RC. All the processes were modeled with experimental criteria and time evolution process. Our system could help the cell proliferation by generating heat for cells. Hence, the present strategy could be implemented for supporting cell therapeutics after transplantation. This implementation would open new design techniques for integrating the interfaces between NIR irradiated and non-irradiated tissues. © 2021, The Author(s).
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BioNano Technology (Department of BioNano Technology)
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