One-pot synthesis of carbon dots with intrinsic folic acid for synergistic imaging-guided photothermal therapy of prostate cancer cells
- Authors
- Le Minh Tu Phan; Gul, Anam Rana; Thi Ngoc Le; Kim, Min Woo; Kailasa, Suresh Kumar; Oh, Kyung Taek; Park, Tae Jung
- Issue Date
- Dec-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- BIOMATERIALS SCIENCE, v.7, no.12, pp.5187 - 5196
- Journal Title
- BIOMATERIALS SCIENCE
- Volume
- 7
- Number
- 12
- Start Page
- 5187
- End Page
- 5196
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82868
- DOI
- 10.1039/c9bm01228a
- ISSN
- 2047-4830
- Abstract
- Photothermal therapy (PTT) is performed using near-infrared-responsive agents, which is proven to be an effective therapeutic strategy against cancer with several advantages including minimal invasion, high effectiveness, and easy implementation. Herein, we report a facile and novel one-pot synthetic approach for the fabrication of polydopamine-folate carbon dots (PFCDs) as theranostic nanocarriers for the image-guided PTT targeting of prostate cancer (PCa) cells that express a prostate-specific membrane antigen (PSMA) (folate hydrolase 1). The as-fabricated PFCDs exhibited several advantages such as easy preparation, high biocompatibility, low toxicity, good water-solubility, and excellent photothermal effect with robust blue fluorescence emission. The PSMA-directed imaging of PCa using PFCDs showed remarkable fluorescence enhancement in LNCap cells as compared to the case of other cells that did not express PSMA. PFCDs exhibited a photothermal effect in the PCa cells when irradiated with an 808 nm laser, which possibly resulted in the complete elimination of the tumor. Thus, these features make PFCDs a promising candidate for PTT. Moreover, PFCD-based PTT provides an effective biomedical platform for cancer therapy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - IT융합대학 > 전자공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82868)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.