The protective effect of hamamelis virginiana stem and leaf extract on fine dust-induced damage on human keratinocytes
- Authors
- Choi, Jiyoung; Yang, Dongki; Moon, Mi Yeon; Han, Gi Yeon; Chang, Moon Sik.; Cha, Joonseok
- Issue Date
- Dec-2021
- Publisher
- MDPI
- Keywords
- Inflammation; Keratinocyte; Particulate matter; Skin barrier; Witch hazel
- Citation
- Cosmetics, v.8, no.4
- Journal Title
- Cosmetics
- Volume
- 8
- Number
- 4
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83105
- DOI
- 10.3390/cosmetics8040119
- ISSN
- 2079-9284
- Abstract
- Witch hazel extracts have been used for decades as cosmetic ingredients in skin care products. Our present study aims to evaluate its potential in anti-pollution products using a previously reported in vitro model. Calcium is a universal second messenger, and we used human respiratory and skin cells to detect changes in intracellular Ca2+ concentrations upon particulate matter contact. Both an increase in pro-inflammatory markers and a decrease in tight junction proteins were confirmed, as previously reported. Witch hazel stem and leaf extract showed significant attenuation of Ca2+ response upon the challenge; it displayed systematic regulations of the signal generator, PAR-2; a pro-inflammatory marker, NF-κB; and a tight junction protein, Occludin. We identified hexagalloylglucose from the extract and concluded that it is a major component regulating protection from particulate matter. Based on these results, witch hazel extract containing hexagalloylglucose is an active ingredient in anti-pollution skin care products. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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