Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders
- Authors
- Lee, Yu Jin; Kim, Soohyun; Gwak, Ah Reum; Kim, Seog Ju; Kang, Seung-Gul; Na, Kyoung-Sae; Son, Young-Don; Park, Juhyun
- Issue Date
- May-2016
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Citation
- COMPREHENSIVE PSYCHIATRY, v.67, pp.59 - 65
- Journal Title
- COMPREHENSIVE PSYCHIATRY
- Volume
- 67
- Start Page
- 59
- End Page
- 65
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8326
- DOI
- 10.1016/j.comppsych.2016.02.013
- ISSN
- 0010-440X
- Abstract
- Objective: This study investigated regional gray matter (GM) volume differences between suicide attempters and suicide non-attempters with major depressive disorder (MDD) and their relationship with psychological risk factors for suicidality. Methods: MDD patients with and without a suicide attempt history (n = 19 in each group) participated. The Hamilton Depression Rating Scale, Clinical Global Impression (severity subscale), Scale for Suicide Ideation (SSI), Risk-Rescue Rating (RRR), Beck Hopelessness Scale (BHS), Barrett Impulsivity Scale, Eysenck Personality Questionnaire, and Ways of Coping Checklist (WCCL) were administered. T1-weighted structural magnetic resonance imaging scans were acquired to evaluate changes in GM volume. Voxel-based morphometry was performed using the SPM 8 software package. Two-sample t-tests were used during second-level group comparison analysis; partial correlation analysis controlling for gender and age identified associations between regional GM volume and psychological measures. Results: Suicide attempters exhibited significantly decreased GM volume in the left angular gyms (p < 0.001, uncorrected) and right cerebellum (p < 0.001, uncorrected). GM volume in the left angular gyms was inversely correlated with BHS scores (r = -0.55, p < 0.01) and positively correlated with the Seeking Social Support subscale of the WCCL (r = 0.43, p < 0.01). Conclusion: These fmdings provide evidence of a neural basis of suicidal behaviors in MDD. In particular, reduced GM volume in the left angular gyms may be a neurobiological marker of suicidality in depressed patients. (C) 2016 Elsevier Inc. All rights reserved.
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Collections - 보건과학대학 > 의용생체공학과 > 1. Journal Articles
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