Drug Resistance Reversal Potential of Nanoparticles/Nanocomposites via Antibiotic's Potentiation in Multi Drug Resistant P. aeruginosa
- Authors
- Pandey, Pratima; Sahoo, Rajashree; Singh, Khusbu; Pati, Sanghamitra; Mathew, Jose; Pandey, Avinash Chandra; Kant, Rajni; Han, Ihn; Choi, Eun-Ha; Dwivedi, Gaurav Raj; Yadav, Dharmendra K.
- Issue Date
- Jan-2022
- Publisher
- MDPI
- Keywords
- nanoparticle; nanocomposite; drug resistance reversal; MIC; graphene oxide-chitosan
- Citation
- NANOMATERIALS, v.12, no.1
- Journal Title
- NANOMATERIALS
- Volume
- 12
- Number
- 1
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83278
- DOI
- 10.3390/nano12010117
- ISSN
- 2079-4991
- Abstract
- Bacteria employ numerous resistance mechanisms against structurally distinct drugs by the process of multidrug resistance. A study was planned to discover the antibacterial potential of a graphene oxide nanosheet (GO), a graphene oxide-zinc oxide nanocomposite (GO/ZnO), a graphene oxide-chitosan nanocomposite (GO-CS), a zinc oxide decorated graphene oxide-chitosan nanocomposite (GO-CS/ZnO), and zinc oxide nanoparticles (ZnO) alone and in a blend with antibiotics against a PS-2 isolate of Pseudomonas aeruginosa. These nanocomposites reduced the MIC of tetracycline (TET) from 16 folds to 64 folds against a multidrug-resistant clinical isolate. Efflux pumps were interfered, as evident by an ethidium bromide synergy study with nanocomposites, as well as inhibiting biofilm synthesis. These nanoparticles/nanocomposites also decreased the mutant prevention concentration (MPC) of TET. To the best of our knowledge, this is the first report on nanomaterials as a synergistic agent via inhibition of efflux and biofilm synthesis.
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