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WS9326H, an Antiangiogenic Pyrazolone-Bearing Peptide from an Intertidal Mudflat Actinomycete
- Authors
- Bae, Munhyung; Oh, Jedo; Bae, Eun Seo; Oh, Joonseok; Hur, Joonseong; Suh, Young-Ger; Lee, Sang Kook; Shin, Jongheon; Oh, Dong-Chan
- Issue Date
- Apr-2018
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.20, no.7, pp.1999 - 2002
- Journal Title
- ORGANIC LETTERS
- Volume
- 20
- Number
- 7
- Start Page
- 1999
- End Page
- 2002
- ISSN
- 1523-7060
- Abstract
- WS9326H (1), a new cyclic peptide, was isolated from a mudflat-derived Streptomyces strain. Based on analysis by 1D/2D NMR, UV spectroscopy, and mass spectrometry, compound 1 was determined to have the gross structure of a cyclic heptapeptide bearing an unprecedented pyrazolone ring connected to a D-arabinitol via an amide bond. The absolute configuration of 1 was established by multistep chemical derivatizations, comprehensive NMR, and LC/MS analyses of the derivatives and quantum mechanics-based computational methods. WS9326H (1) displayed significant antiangiogenesis activity.
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Related Researcher
- Bae, Munhyung
- Pharmacy (Dept.of Pharmacy)