A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.
- Authors
- Kwon, Yun; Kim, Seong-Hwan; Shin, Yoonho; Bae, Munhyung; Kim, Byung-Yong; Lee, Sang Kook; Oh, Ki-Bong; Shin, Jongheon; Oh, Dong-Chan
- Issue Date
- Apr-2014
- Publisher
- MDPI
- Keywords
- sponge; rare actinomycete; Amycolatopsis; benzofuran; cyclopiazonic acid
- Citation
- MARINE DRUGS, v.12, no.4, pp.2326 - 2340
- Journal Title
- MARINE DRUGS
- Volume
- 12
- Number
- 4
- Start Page
- 2326
- End Page
- 2340
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83314
- DOI
- 10.3390/md12042326
- ISSN
- 1660-3397
- Abstract
- Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp. Based on combined spectroscopic analyses, the structures of 1-3 were determined to be a new benzofuran glycoside and new indole alkaloids related to cyclopiazonic acids, a class that has previously only been reported in fungi. The absolute configurations of 1 and 3 were deduced by ECD calculations, whereas that of 2 was determined using the modified Mosher method. Amycolactam (3) displayed significant cytotoxicity against the gastric cancer cell line SNU638 and the colon cancer cell line HCT116.
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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