Separacenes A-D, Novel Polyene Polyols from the Marine Actinomycete, Streptomyces sp.
- Authors
- Bae, Munhyung; Kim, Heegyu; Shin, Yoonho; Kim, Byung Yong; Lee, Sang Kook; Oh, Ki-Bong; Shin, Jongheon; Oh, Dong-Chan
- Issue Date
- Aug-2013
- Publisher
- MDPI
- Keywords
- marine actinomycete; polyene polyol; cytotoxicity; isocitrate lyase
- Citation
- MARINE DRUGS, v.11, no.8, pp.2882 - 2893
- Journal Title
- MARINE DRUGS
- Volume
- 11
- Number
- 8
- Start Page
- 2882
- End Page
- 2893
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83315
- DOI
- 10.3390/md11082882
- ISSN
- 1660-3397
- Abstract
- Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.
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