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New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam
- Authors
- Tran, T.-N.; Sichaem, J.; Nguyen, V.-K.; Nguyen, H.-H.; Cao, T.-T.; Nguyen, T.-P.; Vo, V.-G.; Niamnont, N.; Nguyen, N.-H.; Duong, T.-H.
- Issue Date
- Jan-2022
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- ent-atisane diterpenoid; Euphorbia antiquorum L; Euphorbiaceae; α-glucosidase inhibition
- Citation
- Natural Product Research, v.36, no.2, pp.1 - 8
- Journal Title
- Natural Product Research
- Volume
- 36
- Number
- 2
- Start Page
- 1
- End Page
- 8
- ISSN
- 1478-6419
- Abstract
- Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two new ent-atisane compounds, ent-3α-acetoxy-16β,17,18-trihydroxyatisane (1) and ent-3α,14,16β,17-tetrahydroxyatisane (2) together with three known compounds, 20-deoxy-16-hydroxyingenol (3), ent-14[S],16α,17-trihydroxyatisan-3-one (4), and agallochaol C (5). Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data. Compounds 1–5 were evaluated for α-glucosidase inhibition and cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity against α-glucosidase with the IC50 values of 119.9, 135.5, and 134.3 µM, respectively. None showed activity in cytotoxicity assay. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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