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Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
- Authors
- Kim, Na-Eun; Song, Yoon-Jae
- Issue Date
- Mar-2022
- Publisher
- MICROBIOLOGICAL SOCIETY KOREA
- Keywords
- inflammasome; interferon; severe acute respiratory syndrome corona virus 2
- Citation
- JOURNAL OF MICROBIOLOGY, v.60, no.3, pp.300 - 307
- Journal Title
- JOURNAL OF MICROBIOLOGY
- Volume
- 60
- Number
- 3
- Start Page
- 300
- End Page
- 307
- ISSN
- 1225-8873
- Abstract
- Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms.
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Related Researcher
- Song, Yoon Jae
- BioNano Technology (Department of Life Sciences)