Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist
- Authors
- Sugawara, Reiko; Lee, Eun-Jung; Jang, Min Seong; Jeun, Eun-Ji; Hong, Chun-Pyo; Kim, Jung-Hwan; Park, Areum; Yun, Chang Ho; Hong, Sung-Wook; Kim, You-Me; Seoh, Ju-Young; Jung, YunJae; Surh, Charles D.; Miyasaka, Masayuki; Yang, Bo-Gie; Jang, Myoung Ho
- Issue Date
- 4-Apr-2016
- Publisher
- ROCKEFELLER UNIV PRESS
- Citation
- JOURNAL OF EXPERIMENTAL MEDICINE, v.213, no.4, pp.555 - 567
- Journal Title
- JOURNAL OF EXPERIMENTAL MEDICINE
- Volume
- 213
- Number
- 4
- Start Page
- 555
- End Page
- 567
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8370
- DOI
- 10.1084/jem.20141388
- ISSN
- 0022-1007
- Abstract
- Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.
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