진달래 뿌리 추출물의 알레르기 염증 억제 효과Inhibitory Effect of Rhododendron Mucronulatum Root Extract on Allergic Inflammation
- Other Titles
- Inhibitory Effect of Rhododendron Mucronulatum Root Extract on Allergic Inflammation
- Authors
- 장시성; 이대중; 송지훈; 박도휘; 전찬용; 황귀서
- Issue Date
- Mar-2022
- Publisher
- 대한한방내과학회
- Keywords
- Rhododendron Mucronulatum; allergy; β-hexosaminidase; interleukin; TNF-α; NO
- Citation
- 대한한방내과학회지, v.43, no.1, pp.68 - 78
- Journal Title
- 대한한방내과학회지
- Volume
- 43
- Number
- 1
- Start Page
- 68
- End Page
- 78
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83983
- DOI
- 10.22246/jikm.2022.43.1.68
- ISSN
- 1226-9174
- Abstract
- Objective: In this study, we investigated the protective effect of rhododendron mucronulatum extract (RME) on allergic reactions and inflammation.
Methods: The effect of RME was determined using ELISA and RT-PCR in RBL-2H3 mast cells and RAW 264.7 macrophage cells. We determined cell viability, β-hexosaminidase release, and the synthesis of IL-4 and TNF-α in RBL-2H3 cells. In addition, we determined NO from RAW 264.7 and the gene expression of IL-1β, iNOS, IL-6, TNF-α, and IL-10.
Results: RME inhibited β-hexosaminidase release and synthesis of IL-4 and TNF-α in RBL-2H3 by the anti-DNP IgE plus DNP-HSA stimulation. In addition, RME inhibited the production of NO and the gene expression of IL-1β, iNOS, IL-6, and TNF-α in LPS-stimulated RAW 264.7 cells.
Conclusion: From these results, we concluded that RME possesses anti-allergic activity and anti-inflammatory activity due to the inhibition of mast cells and macrophage function.
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