Mitigation of Gastric Damage Using Cinnamomum cassia Extract: Network Pharmacological Analysis of Active Compounds and Protection Effects in Rats
- Authors
- Lee, Ji Hwan; Kwak, Hee Jae; Shin, Dongchul; Seo, Hye Jin; Park, Shin Jung; Hong, Bo-Hee; Shin, Myoung-Sook; Kim, Seung Hyun; Kang, Ki Sung
- Issue Date
- Mar-2022
- Publisher
- MDPI
- Keywords
- Cinnamomum cassia; acute gastric injury; EtOH/HCl mixture; indomethacin; network pharmacological analysis
- Citation
- PLANTS-BASEL, v.11, no.6
- Journal Title
- PLANTS-BASEL
- Volume
- 11
- Number
- 6
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84046
- DOI
- 10.3390/plants11060716
- ISSN
- 2223-7747
- Abstract
- Gastritis is a common disease worldwide that is caused by various causes such as eating habits, smoking, severe stress, and heavy drinking, as well as Helicobacter pylori infections and non-steroidal anti-inflammatory drugs. Cinnamomum cassia is a tropical aromatic evergreen tree commonly used as a natural medicine in Asia and as a functional food ingredient. Studies have reported this species' anti-obesity, anti-diabetic, and cardiovascular disease suppression effects. We evaluated the potential effects of C. cassia using non-steroidal anti-inflammatory drugs (NSAIDs), ethanol (EtOH), and ethanol/hydrochloric acid (HCB-induced gastric mucosal injury models. C. cassia extracts reduced the area of gastric mucosa injury caused by indomethacin, NSAID, EtOH, and EtOH/HCl. We also applied a network pharmacology-based approach to identify the active compounds, potential targets, and pharmacological mechanisms of C. cassia against gastritis. Through a network pharmacology analysis, 10 key components were predicted as anti-gastritis effect-related compounds of C. cassia among 51 expected active compounds. The NF-KB signaling pathway, a widely known inflammatory response mechanism, comprised a major signaling pathway within the network pharmacology analysis. These results suggest that the anti-gastritis activities of C. cassia may be induced via the anti-inflammatory effects of key components, which suppress the inflammation-related genes and signaling pathways identified in this study.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84046)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.