Procyanidins and Phlobatannins from the Twigs of Rosa multiflora and Their Neuroprotective Activity
- Authors
- Lee, Tae Hyun; Hong, Seong-Min; Yoon, Da Hye; Kim, Sun Yeou; Kim, Chung Sub; Lee, Kang Ro
- Issue Date
- Apr-2022
- Publisher
- American Chemical Society
- Citation
- Journal of Natural Products, v.85, no.4, pp.917 - 926
- Journal Title
- Journal of Natural Products
- Volume
- 85
- Number
- 4
- Start Page
- 917
- End Page
- 926
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84352
- DOI
- 10.1021/acs.jnatprod.1c01033
- ISSN
- 0163-3864
- Abstract
- Three new procyanidins (1-3), two new phlobatannins (6 and 7), a new flavan-3,4-diol glycoside (9), and a new neolignan glycoside (10), along with three previously reported compounds (4, 5, and 8) were isolated from the twigs of Rosa multiflora. The chemical structures of the new compounds (1-3, 6, 7, 9, and 10) were characterized by spectroscopic data interpretation, including NMR (1H and 13C NMR, 1H-1H COSY, HSQC, HMBC, and NOESY) and HRESIMS analysis. Experimental ECD data analysis was conducted to assign the absolute configurations of the new compounds (1-3, 6, 7, 9, and 10). The absolute configuration of the sugar moieties was verified through a chiral derivatization method and LC-MS analysis. All the isolated compounds (1-10) were evaluated for their anti-neuroinflammatory activity based on inhibitory effects on nitric oxide production using a lipopolysaccharide-stimulated murine microglia BV-2 cell line and for their neurotrophic effects on nerve growth factor induction in C6 glioma. © 2022 American Chemical Society and American Society of Pharmacognosy.
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