Effects of compounds isolated from a Litsea japonica fruit extract on the TNF-alpha signaling pathway and cell viability
- Authors
- Won, Jiyeon; Kim, Jung-Eun; Choi, Dong Hwa; Han, Min-Woo; Lee, Doo-Hyung; Kang, Se Chan; Song, Yoon-Jae
- Issue Date
- Mar-2016
- Publisher
- KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
- Keywords
- Pro-inflammatory cytokine; NF-kappa B; Litsea japonica
- Citation
- MOLECULAR & CELLULAR TOXICOLOGY, v.12, no.1, pp.37 - 44
- Journal Title
- MOLECULAR & CELLULAR TOXICOLOGY
- Volume
- 12
- Number
- 1
- Start Page
- 37
- End Page
- 44
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8455
- DOI
- 10.1007/s13273-016-0006-1
- ISSN
- 1738-642X
- Abstract
- Tumor necrosis factor-alpha (TNF-alpha) plays an important role in inflammatory responses. Deregulated activation of TNF-alpha signaling is associated with various inflammatory diseases. In view of the finding that the seventy percent ethanol extract of Litsea japonica (LJE) interferes with TNF-alpha-induced NF-kappa B activation, activity -guided fractionation was performed to identify the active components of the extract. The EtOAc, CH2Cl2 and n-Hexane fractions of LJE induced suppression of inhibitor of kappa B (I kappa B) kinase (IKK), p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK), and significant reduction of TNF-alpha-induced NF-kappa B activation. From the CH2Cl2 fraction, hamabiwalactone A, hamabiwalactone B, litsenolide B2 and litsenolide C2 were identified to inhibit TNF-alpha-induced NF-kappa B activation. The cytotoxic activities of these lactone compounds were additionally evaluated.
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